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Semaglutide is a glucagon-like peptide-1 (GLP-1) agonist that has been approved by the US Food and Drug Administration (FDA) for the treatment of obesity and type 2 diabetes
Your body needs time to adjust to each: GLP-1 receptor: Slows gastric emptying, reduces appetite GIP receptor: Enhances insulin signaling, affects fat metabolism Glucagon receptor: Increases energy expenditure, promotes fat oxidation Jumping to high doses overwhelms these systems, causing: Severe nausea and vomiting Treatment discontinuation Longer overall time to reach therapeutic doses The data: In the Phase 2 NEJM study, participants who started at 4 mg instead of 2 mg had significantly higher rates of gastrointestinal side effects
If you are of childbearing potential, effective contraception is recommended during treatment
NAD+ Therapy Member Pricing $234 & up | $275 & up Cellular-level energy coenzyme that restores mitochondrial and neurological function
In Part X, when we dig into the specific GLP-1 RA peptides, keep in mind how the bodys innate GLP-1 release begins as a response to both the foods we eat and the state of our microbiome
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