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Histopathological findings revealed a significant decrease in the testicular volume, length and diameter of the seminiferous tubules, germinal epithelium height, motility, and viability in the MSG group compared to the control and sham groups, which were consistent with the findings of other reports [54, 56, 57]

This is the toxicity equivalent established by the WHO

It is best to use alpha-arbutin in a lower concentration of 2% or less in serums and creams