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GLP-1 users may differ from nonusers in ways that are not fully captured, such as socioeconomic status, health behaviors, disease severity, medication adherence, or access to care." Lakkis notes that the study also did not report how much weight participants lost, making it difficult to determine how much of the benefit may have been driven by weight reduction itself

Prescribers should be aware that hydroxocobalamin is contraindicated in patients with a known hypersensitivity to cobalt or any other component of the injection solution

For optimal results, use a 11.25 inch needle inserted at 90 degrees into deltoid, vastus lateralis, or ventrogluteal muscle

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"Formulation of Human Proteins as Pharmaceuticals." Pharmaceutical Research, 2012