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Preclinical and clinical studies have uncovered several gastrointestinal effects of metformin, including stimulation of the incretin hormone glucagon-like peptide-1 (GLP-1) [8], slowing of gastric emptying [8], suppression of intestinal glucose absorption [9], inhibition of bile acid resorption [10, 11] and modulation of the gut microbiota [12]

Glucagon-like peptides GLP-1 and GLP-2, predicted products of the glucagon gene, are secreted separately from pig small intestine but not pancreas

The liver naturally produces glutathione, a potent antioxidant that is crucial in battling free radicals and toxins

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Evidence for a lack of inotropic and chronotropic effects of glucagon and glucagon receptors in the human heart