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In addition, Yang et al

It interacts with pathways like the nitric oxide (NO) system and can downregulate pro-inflammatory cytokines while protecting cells from oxidative stress

Patients with impaired liver or kidney function need extra care, especially when using tirzepatide, which contains benzyl alcohol and may increase the risk of metabolic acidosis

GLP-1 Receptor Activation Mechanism Increases insulin secretion in response to glucose, preventing blood sugar spikes Reduces glucagon production, stabilizing blood sugar levels Slows gastric emptying, helping patients feel fuller for longer Regulates appetite and reduces cravings, leading to lower caloric intake Supports long-term fat loss and metabolic stability By addressing multiple metabolic pathways, Semaglutide supports sustainable weight management and improved glucose control

GLP-1s are not prohibited by WADA, which oversees anti-doping efforts in Olympic and Paralympic sports