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Key Differences Between Lupus Rash and Rosacea While both lupus rash and rosacea can cause facial redness and discomfort, several key differences can help distinguish between the two: Appearance Lupus Rash Butterfly-shaped across cheeks and nose Can be scaly or raised Can appear on various body parts Rosacea General redness across the face Typically smooth, may have bumps Mainly on the face Underlying Causes The underlying causes of these conditions are fundamentally different: Lupus Rash: An autoimmune disease causing the body to attack its own tissues