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At the remodeling stage, E2 modulates the secretion of extracellular matrix components and wound tensile strength (Lephart and Naftolin, 2021)

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Stombaugh recommends eating small meals with each dose, staying hydrated, making sure youre taking in electrolytes, and consuming protein shakes to ensure youre getting some nutrition even if you dont have much of an appetite

Patients should be reassured that gastrointestinal symptoms often improve with continued therapy as tolerance develops