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When you consume a substance orally, a percentage of that substance is metabolized by the body before it can actually get into the bloodstream

MPs/NPs have been detected across aquatic species including molluscs, fish, and crustaceans, raising concern about bioaccumulation in humans, with estimated intake ranging from 0.1 to 5 g/week via contaminated food, water and air (Li G

Chem Biol Interact 80:8997 Njlsson R (2005) Glutathione synthetase deficiency

Chasing a larger dose from an online source does not accelerate results, it raises risk and often does the opposite

It affects how well they work and how safe they are