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Likewise, monocyte-derived macrophages in the regenerating muscle do not differentially express the canonical M1 and M2 markers [154,155,156], and macrophage subsets display distinct heterogeneous transcriptional profiles [117, 140] and proliferative capabilities [155, 157], further complicating the process of conducting an unbiased and simultaneous evaluation of all cell populations involved in skeletal muscle regeneration

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