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This work develops the first mathematical model for the GSH antioxidant system in the outer retina, capturing the most essential components for formation of ROS, GSH production, its oxidation in detoxifying ROS, and subsequent reduction by NADPH
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As GSH: GSSG serves as an accurate representation of cellular redox status it is also valuable as a biomarker for patient classification, active monitoring of treatment and the patients physiologic response, and an easily obtained measure of immune exhaustion or oxidative burden (Rossi et al., 2006
