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Loss of extra water-soluble vitamins: After exceeding the required intake, excess water-soluble vitamins (e.g., vitamin C, vitamin B ) are eliminated from the body, resulting in potential nutrient loss

Vitamin B6 intake and risk of stroke: a meta-analysis of prospective studies

In addition, excess vitamin B12 that is not absorbed in the intestine can change the gut microbiome composition and may cause an overgrowth of intestinal bacteria