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Additional analyses may include assessment of peptide stability under varying storage conditions, structural integrity following reconstitution, mapping of interaction patterns within IGF-associated pathways, and observation of downstream intracellular signaling responses within regulated in vitro and preclinical experimental systems

In the SURMOUNT-1 obesity trial, tirzepatide produced mean weight reductions of roughly 1521% depending on dose over 72 weeks ( Jastreboff et al., NEJM 2022

However, long-term human data is limited