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Berberine - one of the most-studied botanicals in the glucose support category - is well-documented to have lower oral bioavailability partly because of that first-pass effect

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It plays a critical role in detoxification, immune support, and cellular repair

Patients can receive vaccinations while being treated with DMF and most surgical interventions do not necessitate FAE discontinuation, other than those on the gastrointestinal system (as DMF is metabolised by gut esterases)