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Recommended conditions for lyophilized GLP-1S are: Room temperature (unopened, lyophilized): Suitable for short periods when kept sealed, dry, and protected from light

34,35 Subsequently, GLP-1 undergoes enzymatic degradation facilitated by dipeptidyl peptidase IV (DPP-4), leading to the loss of its biological efficacy

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While these symptoms have many potential causes, they require evaluation to rule out thyroid pathology, given the FDA's boxed warning regarding thyroid C-cell tumors

Use of stomach acid-resistant capsules (DRcaps) further protect stability