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[26] None of the studies reported significant adverse effects or follow-up beyond the study period (Table 1)

Emphasizes not to double doses

Jan 3, 2026 Dark circles under eyes create persistent cosmetic concern affecting appearance across all ages and skin types, with multiple underlying causes including thin periorbital skin revealing underlying vasculature, hyperpigmentation from melanin accumulation, shadows from volume loss and fat pad descent, and fluid retention creating puffiness accentuating darkness

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