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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

Add fiber to your diet: Add more fruits, vegetables, and whole grains to increase fiber intake

After twenty years of swinging hammers and operating power tools, my right elbow started giving me serious problems about two years ago

Pharmacol Ther 71, 15391

Action step: Incorporate strength training 2-3 times per week to prevent muscle loss during weight loss