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Considering the positive impact of Nrf2 in ameliorating oxidative stress, a number of bioactive components that exert protective effect against APAP-associated hepatotoxicity have been identified and reported, including caffeic acid that activates the Keap1-Nrf2 antioxidant defense system (Pang et al., 2016), carnosic acid that promotes nuclear translocation of Nrf2 ( via AMP-activated kinase/Akt/glycogen synthase kinase 3 pathway (Wang et al., 2016)
Biochemistry 29 , 1000910018
HCV serves as a prime example: its NS3/4A protease cleaves MAVS at Cys508, releasing it from the outer mitochondrial membrane and disrupting RLR-mediated IFN signaling (Mukherjee et al., 2011
Cons: no effect on body glutathione stores
Feki and Hibaoui 2018)
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