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In one landmark trial, adults without diabetes who took the highest weekly dose lost an average of 20.9 percent of their body weight over 72 weeks, compared with 3.1 percent on placebo, and more than half reached at least a 20 percent reduction (SURMOUNT-1 trial, New England Journal of Medicine, 2022)
Diabetes Care 2022;45:2753-2786
L.ZhangZ.YaoY
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As a result, contemporary guidelines recommend aspirin only for carefully selected populations, such as individuals with elevated cardiovascular risk or hereditary colorectal cancer syndromes
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