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Long term secretion of Exe4 peptide in the genome-edited mice To examine the prolonged expression of Exe4 following a single genome editing procedure, we administrated HITI components, including the scExe4 donor with gRNA expression cassette and Cas9-expression DNAs, via intravenous injection of DNA-loaded LNPs into Balb/c mice (Fig
doi: 10.3390/jcdd9060174 109 WeiCSongTYuanHLiXZhangXLiangXet al
doi:10.4162/nrp.2010.4.3.229
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While there are medications currently available for treating OUD, such as methadone and buprenorphine, these drugs come with their own set of challenges, including the potential for misuse
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