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This balance underscores why multiple trial arms were necessary: without testing a range of dosages, investigators would not have uncovered these differences in outcome patterns
(2) depleted hepatic glutathione levels and its intermediates despite unchanged level of reactive oxygen species, suggesting glutathione consumption exceeds production due to systemic oxidative stress after AKI
Treatment response evaluation should focus on objective measures relevant to the specific indication being treated
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Some patients may notice minimal change, particularly if their diabetes is well-controlled and they are taking other glucose-lowering medications such as metformin
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