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Activation of AMPK enhances myocardial energy efficiency and reduces oxidative stress, while anti-remodeling actions limit ventricular hypertrophy and fibrosis ( 3.2.4 Summary Metformin is a safe and effective adjunct in HF management, particularly for patients with type 2 diabetes, and shows promise in selected non-diabetic HF populations

doi:10.1021/bi962272d

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