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In Treg cells (CD4+ Poxp3+), elevated levels of the mitochondrial TCA cycle metabolite -ketoglutarate (KG) induce a profound metabolic rewiring including oxidative metabolism and altered lipid homeostasis through increasing DNA demethylation, which actively restricting Treg differentiation and shifting the balance toward an inflammatory phenotype

The WHO recently recognized obesity defined as a body mass index of 30 or greater as a chronic condition

Ophthalmology and Therapy

Also, safety concerns are higher

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