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[11] Long-term metformin therapy reduces calcium-dependent intrinsic-factor binding, lowering B12 absorption and potentially necessitating higher or more frequent parenteral doses

Interestingly, much of the research has been based on doses far exceeding the recommended daily intake, both in individuals with pathological conditions and in healthy subjects

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Measuring vitamin B-12 bioavailability with [13C]-cyanocobalamin in humans

By stimulating blood vessel growth, the peptide ensures that damaged tissues receive an adequate supply of oxygen and nutrients, while also facilitating the removal of metabolic waste