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The high molecular mass of GLP-1s suggests that transfer across the placenta wouldnt be expected, but given the lack of knowledge, women using them for weight loss (who do not have diabetes) are advised to stop before trying to conceive

For patients with chronic kidney disease, protein intake should be individualized with medical supervision

Fragile X syndrome (FXS) [327] is the most common mutation-based form of intellectual disability Fragile X syndrome (FXS) Its prevalence rate accounts for about 1 in 4000-5000 males and 1 in 6000-8000 females [328, 329]

For older patients or those with existing sarcopenia, this is clinically significant and entirely invisible on a standard weighing scale

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