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The lack of plaque rupture and thrombosis and the subsequent effect on the heart or cerebral ischemia have often led to questions of the relevance of these models for validation of novel pharmaceuticals in the field of CV disease (52)

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Although several routes for the production of butyrate have been described, in human gut microbiota, butyrate is mainly synthesized from acetyl-coenzyme A (Ac-CoA) obtained from the breakdown of complex carbohydrates (e.g., xylan, starch) as a precursor (18, 37)

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