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No Phase I, II, or III trial has been completed and published in a peer-reviewed journal with systematic adverse-event reporting

When glutathione levels are depleted - as they consistently are in Hashimoto's thyroiditis, Graves' disease, and hypothyroidism - the consequences cascade: oxidative thyroid damage, protein modification, autoantigen formation, immune activation, and progressive thyroid destruction

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Research suggests the important role of glutathione in detoxification processes

PMC 2172237