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These include people with a history of pancreatitis (since both alcohol and GLP-1 drugs stress the pancreas), those with liver disease or cirrhosis, individuals with a personal or family history of alcohol misuse, and patients with type 1 or type 2 diabetes who are also taking insulin or other glucose-lowering medications
Ideal candidates are psoriasis patients with BMI 30 (or 27 with comorbidity), particularly those with suboptimal biologic response, metabolic syndrome, type 2 diabetes, established CVD, or MASH
Origin: A synthetic melanocortin receptor agonist derived from -MSH (alpha-melanocyte-stimulating hormone)
Skin brightening plateau: The 12-week clinical trial by Weschawalit et al
Ipamorelin studies also indicate that the peptide may influence glucose metabolism and insulin sensitivity
