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Lower Risk Across All Key Outcomes with GLP-1RA Compared with DPP-4 inhibitors, GLP-1RA use was associated with significantly lower risks of MACE (hazard ratio [HR]: 0.66), VTE (HR: 0.49), kidney disease progression (HR: 0.77), and all-cause mortality (HR: 0.26)
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Abbreviations ER endoplasmic reticulum PDH pyruvate dehydrogenase TCA tricarboxylic acid CPT1 carnitine palmitoyltransferase 1 TMAO trimethylamine N-oxide OCTN2 organic cation transporter novel 2 BBB blood-brain barrier PCD primary carnitine deficiency FAO fatty acid oxidation CPT2 carnitine palmitoyltransferase 2 CAT carnitine acetyltransferase INF- interferon TNF- tumor necrosis factor- IDH1 isocitrate dehydrogenase 1 ROS reactive oxygen species PPAR peroxisome proliferator-activated receptor PPAR peroxisome proliferator-activated receptor GBM glioblastoma ER+ estrogen receptor positive CRC colorectal cancer OCT organic cation transporter IngMeb ingenol mebutate
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Mounjaro may be suitable for adults who: Have a BMI of 30kg/m2 or higher, or Have a BMI of 27kg/m2 or higher with weight-related conditions, such as type 2 diabetes, high blood pressure, high cholesterol or sleep apnoea
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