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While typically associated with oxidative stress conditions, glutathionylation also occurs under basal physiological conditions, especially during the regulation or regeneration of thiol-containing enzymes like peroxidases

The antidiabetic drugs metformin and acarbose lower fasting glucose with little risk of hypoglycemia, in contrast to drugs like sulfonylureas that directly stimulate insulin secretion

Allen et al

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As we age, our NAD levels naturally decline