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In mice, treated females generated oocytes with improved spindle integrity and reduced DNA fragmentation

Decreased sympathetic nerve firing leads to arterial vasodilation, resulting in reduced total peripheral resistance (TPR), and venodilation, resulting in decreased venous return (preload)

Compared with GPX1-3, GPX4 is also involved in the reduction of complex membrane-associated phospholipid hydroperoxides such as phosphatidylcholine hydroperoxide and cholesterol hydroperoxide, in addition to reacting with soluble, low molecular weight hydroperoxides such as t-butyl hydroperoxide and cumene hydroperoxide [68]

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