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doi: 10.1126/scitranslmed.aar7047 9 OvergaardRNavarriaAHertzCIngwersenS

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Ongoing care and prescribing decisions are based on medical history, questionnaire responses, and provider discretion.

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Much evidence suggests that activation of anorexogenic proopiomelanocortin (POMC) neurons and simultaneous inhibition of orexigenic neuropeptide Y/Agouti-related peptide (NPY/AgRP) neurons in the ARC appears to be one of the major mechanisms for GLP-1R mediated inhibition of food intake