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261 Benzodiazepines are also well known to cause tolerance (the need for increasing doses to experience the same effect) and addiction with potentially life-threatening consequences
10.1056/NEJMp1314078 53 FadiniG
Future research will likely focus on the specific regulatory mechanisms of these metabolic processes in different neuronal populations, such as the lactate shuttle pathway and monocarboxylate transporter (MCT)-mediated interactions, how they are involved in the pathological processes of neurodegenerative diseases through key signaling pathways, and how to target specific metabolic enzymes and transporters for therapeutic intervention (Blanger et al., 2011)
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1 But they have also proven to be effective in helping people lose weight, and three GLP-1 drugs Wegovy, Zepbound, and Saxenda have FDA approval to be used for chronic weight management
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