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Mechanisms of Action and Therapeutic Rationale Physiological Basis of GLP-1 Action GLP-1, an incretin hormone, plays a crucial role in glucose metabolism and appetite regulation, influencing insulin secretion, insulin-sensitivity, and gastric emptying [15] [16]

Patients who began GLP-1 therapy in 2024 and 2025 have reached or are approaching their target weight, and many are discovering that the final 10 to 20 percent of their body transformation requires surgical refinement

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