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This is relevant for patients who miss doses: extending the course at a consistent daily dose may be preferable to increasing the daily dose to "catch up." The dose-response relationship is not linear at the extremes
PAM variants are also more common in people with diabetes
The goal is safety and tolerance
Some people may feel appetite changes
Upon initiation of a GLP-1 RAs and during up-titration, it is advisable for cardiologists to counsel their patients to take smaller meals, eat slowly and stop before feeling full, and avoid fatty or spicy foods ( 4 Conclusion GLP-1 RAs seem to emulate the evolution of statins and sodium-glucose co-transporter-2 inhibitors in terms of being approved for indications other than their initial indication and becoming promising agents in CV medicine which will continue to grow
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