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A phase 2 clinical trial showed that retatrutide treatment for 48 weeks led to significant body weight loss in obese patients (NCT04881760)
& Mourrain, P
The treatment regimen included a preventive dose 60 15 minutes prior to MCAO, followed by daily doses for 7 days after reperfusion
Its sequence (HXQGTFTSDYSIXLDEEAQAAFIEYLIAGGPSSGAPPPS-NH) incorporates key structural modificationsincluding a C18 fatty diacid chain for extended half-lifethat distinguish it mechanistically from first-generation incretin-based research peptides
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