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For someone losing 50 lb, this could mean 10-20 lb of muscle tissue lost alongside the fat
The amount of weight loss is variable according to the type of GLP1-RAs administered, for example moderate with exenatide and dulaglutide, and robust with semaglutide and liraglutide, thus possibly explaining the diverse impacts on T levels ( via weight loss and improvement of metabolic status as opposed to the direct tissue-specific effects of GLP1-RAs that go beyond the weight-lowering potential
Participants were randomly assigned to receive weekly injections of retatrutide at doses of 1 mg, 4 mg, 8 mg or 12 mg, or a placebo for 48 weeks
M., Qiao, F., Degrace, P., Chen, L.-Q., Zhang, M.-L., & Du, Z.-Y
It's important to note that medications licensed for diabetes (such as Ozempic) should not be used off-label for weight management, particularly during periods of supply constraints, as this can affect availability for patients with diabetes who need these medicines
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