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Diabetes Care 27 , 26282635 (2004)

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Critical research gaps include appropriate dosing regimens, optimal treatment duration, safety profiles with long-term use, actual efficacy in human subjects, drug-drug interactions when peptides are combined, and comparative effectiveness versus standard treatments, says Herring

Understanding how to properly use tirzepatide is essential for safety and effectiveness

Accumulating data support the systemic benefits of semaglutide (and potentially other GLP-1RA-based therapies) in people with obesity, meaning that cardiologists and other clinicians must become familiar with prescribing them particularly once market competition makes these drugs more accessible