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Results from another uncontrolled intervention in 21 HIV-positive patients suggested that long-term (two to four years) oral ALCAR supplementation (1.5 g/day) may be a beneficial adjunct to antiretroviral therapy to improve neuropathic symptoms in some HIV-infected individuals (80, 81)

Safety Considerations Most common adverse effects: Nausea Vomiting Diarrhea GI intolerance Rare but important: Pancreatitis Gallbladder disease Potential thyroid C-cell concerns in animal models Careful patient selection and dose titration remain essential

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These drugs were not originally tested for long-term safety in healthy individuals