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Dual or triple-agonist needs: Patients who benefit from GIP co-agonism (tirzepatide) or who may need triple agonism (retatrutide, targeting GLP-1, GIP, and glucagon receptors) require injectable formulations that aren't currently available as oral small molecules

Patients with Graves' disease may already experience gastrointestinal symptoms related to hyperthyroidism, such as increased bowel frequency or diarrhoea

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Nonetheless, this cooperative effect is subject to variations related to caffeine tolerance, coffee intake levels, as well as individual health condition parameters