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113 NannyaY.ShinoharaA.IchikawaM.KurokawaM
Clinical evidence: The STEP (Semaglutide Treatment Effect in People with obesity) clinical trial program is the largest body of evidence supporting any weight loss medication
It stabilizes delicate mitochondrial membranes, significantly reduces the generation of destructive reactive oxygen species (ROS), and protects the cell from ferroptosis, a severe form of iron-dependent cell death
This may occur, for example, if there is a problem with the machine
Metabolic signs: Weight loss that feels rapid but leaves you feeling depleted rather than energized, a plateau in fat loss despite continued calorie restriction, difficulty maintaining lean body composition
