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GLP-1 receptor activation produces appetite suppression through hypothalamic signaling, slows gastric emptying to promote prolonged feelings of fullness, improves insulin secretion in response to meals, and reduces glucagon secretion that would otherwise raise blood sugar levels

Perkovic V, Jardine MJ, Neal B, Bompoint S, Heerspink HJL, Charytan DM et al

Others lose 8-10%

Because stopping GLP-1 therapy can minimize the long-term health gains

The role of the endocannabinoid system in the gut has been studied extensively and it is now well-established that cannabinoids modulate gastrointestinal motility, secretion and inflammation