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Dark urine accompanied by jaundice, severe abdominal pain, or significantly reduced urine output requires immediate medical evaluation to exclude these serious complications

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Importantly, MEDI4166 was able to induce glucose-stimulated insulin secretion in INS1 -cells expressing endogenous GLP-1R (Supplementary Fig

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When p53 transcriptional activity in response to 5-FU treatment was measured, the mRNA and protein levels of p21, which is a p53 target gene, were decreased in the GST WT -p53-expressing cells

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