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Thyroid concerns arise because semaglutide was studied in animals with genetic predisposition to thyroid cancer, but this has not been observed in human trials

Common gastrointestinal effects (Phase 2 NEJM) Retatrutide GI side effects at 12 mg in the Phase 2 NEJM trial Effect Nausea Rate at 12 mg Up to 25% Effect Diarrhea Rate at 12 mg Up to 23% Effect Vomiting Rate at 12 mg Up to 26% Effect Constipation Rate at 12 mg Up to 16% GI symptoms were most common during dose escalation and were usually mild to moderate

Give yourself time between dose increases: Your provider may adjust your schedule to match your tolerance

Step 3: Get your medication shipped or prepared for pickup once approved

If you can only eat five bites, make those five bites chicken, fish, or eggs