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Together, these results support the hypothesis that cysteine derived from lysosomal cystine efflux limits the activity of the -glutamyl cycle and GSH synthesis
Clin Pharmacol Ther 2003
By using 1,1-dioctadecyl-3,3,3,3-tetramethylindotricarbocyanine iodide (DiR), a near IR fluorescent and hydrophobic carbocyanine, as a fluorescence tracking agent, whole body imaging demonstrated that COXP micelles delivered DiR to mouse brains about 20 times higher than DiR administered alone [52]
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The lessons span several mechanistic families
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