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When to throw out Ozempic You should only be concerned if your Ozempic: Was exposed to temperatures above 86F like being left in a hot car during summer Has been frozen Looks different (youll see cloudy, discolored, or has particles floating in it) Has been stored at room temperature for more than 56 days/8 weeks after first use In these situations, the safest thing to do is discard the pen and use a new one