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PMID: 27687303

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Specifically, enhanced CTSB-mediated activation of trypsinogen to trypsin, combined with inefficient degradation of trypsin and trypsinogen due to immature CTSL, may contribute to intrapancreatic trypsin accumulation and the progression of pancreatitis, 228 as discussed in the cathepsin dysfunction section

Muti P, Quattrin T, Grant BJ, et al

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