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Alcohol Several studies investigating exendin-4, liraglutide, dulaglutide and semaglutide in rats and mice found a decrease in alcohol use, which was mediated by mesolimbic dopamine pathways involving the nucleus accumbens, the ventral tegmental area and the ventral hippocampus, the dorso-lateral septum, and the nucleus of the solitary tract 59,60,61,63,64,65,66,67,68,69,72,74,75,76,77,79,80,81,82,106
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In this image you can see how these lesions evolve over time when the patient is young, both increasing in size and darkening in pigmentation
The evidence for phentermine with GLP-1 medications is mixed, and the direct comparison between phentermine and GLP-1 agents generally favors the GLP-1 medications for both efficacy and safety
