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Storage Pill: No refrigeration required Injection: Often needs refrigeration 5

The appetite regulation centers in the brain need time to adjust to sustained GLP-1 receptor activation

Efficacy, safety, and effect on -cell function after 2 years of treatment with once-weekly semaglutide in patients with type 2 diabetes. Diabetes Care

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For GLP-1 medications, this translates to: Semaglutide Steady state reached after approximately 45 weeks of weekly injections Dulaglutide Steady state reached after approximately 24 weeks Liraglutide Steady state reached after approximately 3 days of daily injections Exenatide extended-release Steady state reached after approximately 67 weeks Short-acting agents (exenatide immediate-release, lixisenatide) Steady state reached within 12 days Once steady state is achieved, the medication concentration remains relatively constant, fluctuating only slightly between doses