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During the initial trimester of pregnancy, fetal mitochondria exhibit a degree of immaturity and reduced expression of OCTs, suggesting that the administration of metformin in the first trimester is associated with a relatively low-risk profile

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The procedure takes only a few minutes and is well-tolerated by most patients

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For Wegovy (higher-dose semaglutide for weight management), rates were higher, affecting approximately 29.3% of patients across the STEP clinical trials, with most cases occurring during dose escalation phases