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Here's what the clinical evidence shows: Semaglutide (Wegovy): In the STEP 4 trial, people taking the highest dose of semaglutide lost an average of 17.4% of their body weight over 68 weeks
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A large network meta-analysis comparing weight loss and side effects found more treatment stops at the highest doses, especially due to nausea and vomiting, for both drugs, with slightly higher rates at maximum doses
Stokman, G., Qin, Y., Rcz, Z., Hamar, P
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